ご挨拶 – 高木医院

高木医院は昭和５９年（1984年）に先代院長である私の父が「高木外科胃腸科医院」として開院いたしました。

当時仙台市付近は、郊外へ住宅地区を発展している時であり、この地区も新築の住宅が次々建築されている最中でした。父の談では、周辺に他の医療施設があまりなかったため、外科、内科はもとより全ての科の患者を受け入れていた状態であったそうです。ちなみに父は私とともに診療をしておりましたが、平成３０年（2018年）に退職しております。

私は東北大学医学部（現在の医学部医学科）を卒業後勤務医を経て、平成２０年より実家であるこの医院に戻り１２年が経ち、現在令和に至っております。

東北大学病院消化器内科（旧第３内科）に長く在籍しておりましたので、消化管（胃・小腸・大腸）の内視鏡検査・治療や造影検査、特に大腸がん、ポリープ、炎症性腸疾患（潰瘍性大腸炎・クローン病）の診断・治療に携わる機会が多かったため、それら得意分野を活かしたクリニックにしたいと思っております。

上記の疾患では特殊な検査・治療が必要となりますが、大きな病院の診療レベルと同等にするよう最新の検査機器や治療を取り入れ、私自身日々精進していく所存であります。

内視鏡検査件数は増加の一途をたどり、現在では非常勤専門医の先生方のお力をおかりして充実した検査内容、待ち時間の短縮を図っている次第です。

また当院では、糖尿病や高脂血症等生活習慣病の増加に対しても、より高度な専門医療を行うため非常勤専門医の先生に来ていただき、ご指導を受けるとともに専門外来診療を行っております。

今後もよりよい医療を提供するべくなお一層努力いたす所存です。何卒よろしくお願いいたします。

令和２年４月吉日

高木医院
院長　高木承

専門科目	内科、消化器科（胃腸科）
略歴	平成5年東北大学医学部卒東北大学大学院医学系研究科卒医学博士（東北大学）
大学所属医局	東北大学消化器内科
所属学会等	日本内科学会認定内科医日本消化器病学会専門医、全国評議員日本消化器内視鏡学会専門医、指導医、全国評議員日本消化器がん検診学会認定医、指導医、東北支部評議員日本医師会認定産業医
学校医（内科）管理医	仙台市立南中山中学校仙台市立長命ケ丘中学校
産業医	社会福祉法人やまとみらい福祉会

論文太字タイトル：first author	Long-term course of inflammatory bowel disease after the Great East Japan Earthquake. T Miyazawa, H Shiga, S takagi, et al.　J Gastroenterol Hepatol. 2018 Dec;33(12):1956-1960. Hemodynamics of rectal varices. S Takagi, Y Kinouchi, et al.　J Gastroenterol. 2006 Jun;41(6):611-2. Hla-B genotype in Japanese patients with Crohn’s disease. Y Kinouchi, K Matsumoto, S Takagi, et al.　Dis Colon Rectum. 2003 Oct;46(10 Suppl):S10-4. Rupture of rectal varices treated with endoscopic variceal ligation. M Shiraki, S Takagi, et al.　Surg Laparosc Endosc Percutan Tech. 2004 Oct;14(5):295-9. Changes of faecal microbiota in patients with Crohn’s disease treated with an elemental diet and total parenteral nutrition. H Shiga, T Kajiura, S Takagi, et al.　Dig Liver Dis. 2012 Sep;44(9):736-42. Genotype and phenotype relation in inflammatory bowel disease. Y Kinouchi, K Negoro, S Takagi, et al.　J Gastroenterol. 2005 Mar;40 Suppl 16:21-4. Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden’s disease. K Umemura, S Takagi, et al.　World J Gastroenterol. 2008 Oct 7;14(37):5755-9. CARD15/NOD2 mutational analysis in Japanese patients with Crohn’s disease. M Sugimura, Y Kinouchi, S Takagi, et al.　Clin Genet. 2003 Feb;63(2):160-2. HLA-DRB1 alleles influence clinical phenotypes in Japanese patients with ulcerative colitis. Y Matsumura, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2008 May;71(5):447-52. TNFSF15 transcripts from risk haplotype for Crohn’s disease are overexpressed in stimulated T cells. Y Kakuta, U Ueki, S Takagi, et al.　Hum Mol Genet. 2009 Mar 15;18(6):1089-98. Author reply: Comment to “Changes of faecal microbiota in patients with Crohn’s disease treated with an elemental diet and total parenteral nutrition”. H Shiga, T Kajiura, S Takagi, et al.　Dig Liver Dis. 2013 Feb;45(2):177-8. Efficacy and safety of endoscopic balloon dilation for Crohn’s strictures. E Nomura, S Takagi, et al.　Dis Colon Rectum. 2006 Oct;49(10 Suppl):S59-67. Significance of colonoscopy in patients with intestinal graft-versus-host disease after hematopoietic stem cell transplantation. S Oomori, S Takagi, et al.　Endoscopy. 2005 Apr;37(4):346-50. Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. N Obana, S Takagi, et al.　Intern Med. 2003 Feb;42(2):150-3. Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn’s disease: a retrospective cohort study. H Shiga, T Miyazawa, S Takagi, et al.　BMJ Open. 2013 Feb 8;3(2):e002294. IL-10 deficiency leads to somatic mutations in a model of IBD. Y Sato, S Takahashi, S Takagi, et al.　Carcinogenesis. 2006 May;27(5):1068-73. Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn’s disease: A randomized-controlled trial. S Takagi, K Utsunomiya, et al.　Aliment Pharmacol Ther. 2006 Nov 1;24(9):1333-40. HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis. H Aizawa, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2009 Jun;73(6):569-74. Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB11502. A Mochida, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2007 Aug;70(2):128-35.* Multiparameter analysis for discreet differential diagnosis of mucosa-associated lymphoid tissue lymphoma in the intestine. E Nomura, S Takagi, et al.　In Vivo. 2004 Jul-Aug;18(4):437-41. Clinical course and longterm prognosis of Japanese patients with Crohn’s disease: predictive factors, rates of operation, and mortality. T Oriuchi, N Hiwatashi, S Takagi, et al.　J Gastroenterol. 2003;38(10):942-53. Scheduled maintenance therapy with infliximab improves the prognosis of Crohn’s disease: a single center prospective cohort study in Japan. S Takahashi, S Takagi, et al.　Tohoku J Exp Med. 2010 Mar;220(3):207-15. Quality of life of patients and medical cost of “half elemental diet” as maintenance therapy for Crohn’s disease: secondary outcomes of a randomised controlled trial. S Takagi, K Utsunomiya, et al.　Dig Liver Dis. 2009 Jun;41(6):390-4. What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis. H Shiga, S Takagi, et al.　Digestion. 2010;81(2):104-12. Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis. E Nomura, Y Kinouchi, S Takagi, et al.　Genes Immun. 2004 Sep;5(6):477-83. Panniculitis of the descending colon caused by enterocolic phlebitis: a case report. M Shiraki, S Takagi, et al.　Tohoku J Exp Med. 2004 Apr;202(4):299-304. Photodynamic therapy of intestinal tumors with mono-L-aspartyl chlorin e6 (NPe6): a basic study. T Kikuchi, T Asakura, S Takagi, et al.　Anticancer Res. 2003 Nov-Dec;23(6C):4897-900. Relationship between microsatellite instability and telomere shortening in colorectal cancer. S Takagi, Y Kinouchi, et al.　Dis Colon Rectum. 2000 Oct;43(10 Suppl):S12-7. Strong telomerase activity of B lymphocyte from mesenteric lymph nodes of patients with inflammatory bowel disease. S Takagi, Y Kinouchi, et al.　Dig Dis Sci. 2003 Oct;48(10):2091-4. Telomere shortening in the colonic mucosa of patients with ulcerative colitis. Y Kinouchi, N Hiwatashi, S Takaghi, et al.　J Gastroenterol. 1998 Jun;33(3):343-8. Effect of weekend 5-aminosalicylic acid (mesalazine) enema as maintenance therapy for ulcerative colitis: results from a randomized controlled study. H Yokoyama, S Takaghi, et al.　Inflamm Bowel Dis. 2007 Sep;13(9):1115-20. High Ki-67 labeling index in human colorectal cancer with microsatellite instability. S Takagi, S Kumagai, et al.　Anticancer Res. 2002 Nov-Dec;22(6A):3241-4. Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer. S Takagi, Y Kinouchi, et al.　Anticancer Res. 2002 Sep-Oct;22(5):2749-52. Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients. K Negoro, S Takahashi, S Takagi, et al.　Dis Colon Rectum. 2000 Oct;43(10 Suppl):S29-33. Useful endoscopic findings for early diagnosis of ulcerative colitis associated colorectal cancer. Y Sato, S Takagi, et al.　Endoscopy. 2008 Sep;40 Suppl 2:E71-2. Prognostic and diagnostic significance of tumor budding associated with β-catenin expression in submucosal invasive colorectal carcinoma. K Umemura, S Takagi, et al.　Tohoku J Exp Med. 2013 Jan;229(1):53-9. Lack of association between IBD5 and Crohn’s disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease. M Tosa, K Negoro, S Takagi, et al.　Scand J Gastroenterol. 2006 Jan;41(1):48-53. Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14. N Obana, S Takahashi, S Tkagi, et al.　Scand J Gastroenterol. 2002 Jun;37(6):699-704. Microsatellite instability and loss of heterozygosity in the nondysplastic colonic epithelium of ulcerative colitis. S Takahashi, Y Kojima, S Takagi, et al.　J Gastroenterol. 2003;38(8):734-9. Crohn’s disease is associated with novel polymorphisms in the 5′-flanking region of the tumor necrosis factor gene. K Negoro, Y Kinouchi, S Takagi, et al.　Gastroenterology. 1999 Nov;117(5):1062-8. Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas. S Takagi, Y Kinouchi, et al.　Cancer. 1999 Oct 15;86(8):1431-6.

論文
太字タイトル：first author

Long-term course of inflammatory bowel disease after the Great East Japan Earthquake.
T Miyazawa, H Shiga, S takagi, et al.　J Gastroenterol Hepatol. 2018 Dec;33(12):1956-1960.

Hemodynamics of rectal varices.
S Takagi, Y Kinouchi, et al.　J Gastroenterol. 2006 Jun;41(6):611-2.

Hla-B genotype in Japanese patients with Crohn’s disease.
Y Kinouchi, K Matsumoto, S Takagi, et al.　Dis Colon Rectum. 2003 Oct;46(10 Suppl):S10-4.

Rupture of rectal varices treated with endoscopic variceal ligation.
M Shiraki, S Takagi, et al.　Surg Laparosc Endosc Percutan Tech. 2004 Oct;14(5):295-9.

Changes of faecal microbiota in patients with Crohn’s disease treated with an elemental diet and total parenteral nutrition.
H Shiga, T Kajiura, S Takagi, et al.　Dig Liver Dis. 2012 Sep;44(9):736-42.

Genotype and phenotype relation in inflammatory bowel disease.
Y Kinouchi, K Negoro, S Takagi, et al.　J Gastroenterol. 2005 Mar;40 Suppl 16:21-4.

Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden’s disease.
K Umemura, S Takagi, et al.　World J Gastroenterol. 2008 Oct 7;14(37):5755-9.

CARD15/NOD2 mutational analysis in Japanese patients with Crohn’s disease.
M Sugimura, Y Kinouchi, S Takagi, et al.　Clin Genet. 2003 Feb;63(2):160-2.

HLA-DRB1 alleles influence clinical phenotypes in Japanese patients with ulcerative colitis.
Y Matsumura, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2008 May;71(5):447-52.

TNFSF15 transcripts from risk haplotype for Crohn’s disease are overexpressed in stimulated T cells.
Y Kakuta, U Ueki, S Takagi, et al.　Hum Mol Genet. 2009 Mar 15;18(6):1089-98.

Author reply: Comment to “Changes of faecal microbiota in patients with Crohn’s disease treated with an elemental diet and total parenteral nutrition”.
H Shiga, T Kajiura, S Takagi, et al.　Dig Liver Dis. 2013 Feb;45(2):177-8.

Efficacy and safety of endoscopic balloon dilation for Crohn’s strictures.
E Nomura, S Takagi, et al.　Dis Colon Rectum. 2006 Oct;49(10 Suppl):S59-67.

Significance of colonoscopy in patients with intestinal graft-versus-host disease after hematopoietic stem cell transplantation.
S Oomori, S Takagi, et al.　Endoscopy. 2005 Apr;37(4):346-50.

Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders.
N Obana, S Takagi, et al.　Intern Med. 2003 Feb;42(2):150-3.

Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn’s disease: a retrospective cohort study.
H Shiga, T Miyazawa, S Takagi, et al.　BMJ Open. 2013 Feb 8;3(2):e002294.

IL-10 deficiency leads to somatic mutations in a model of IBD.
Y Sato, S Takahashi, S Takagi, et al.　Carcinogenesis. 2006 May;27(5):1068-73.

Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn’s disease: A randomized-controlled trial.
S Takagi, K Utsunomiya, et al.　Aliment Pharmacol Ther. 2006 Nov 1;24(9):1333-40.

HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis.
H Aizawa, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2009 Jun;73(6):569-74.

Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502.
A Mochida, Y Kinouchi, S Takagi, et al.　Tissue Antigens. 2007 Aug;70(2):128-35.

Multiparameter analysis for discreet differential diagnosis of mucosa-associated lymphoid tissue lymphoma in the intestine.
E Nomura, S Takagi, et al.　In Vivo. 2004 Jul-Aug;18(4):437-41.

Clinical course and longterm prognosis of Japanese patients with Crohn’s disease: predictive factors, rates of operation, and mortality.
T Oriuchi, N Hiwatashi, S Takagi, et al.　J Gastroenterol. 2003;38(10):942-53.

Scheduled maintenance therapy with infliximab improves the prognosis of Crohn’s disease: a single center prospective cohort study in Japan.
S Takahashi, S Takagi, et al.　Tohoku J Exp Med. 2010 Mar;220(3):207-15.

Quality of life of patients and medical cost of “half elemental diet” as maintenance therapy for Crohn’s disease: secondary outcomes of a randomised controlled trial.
S Takagi, K Utsunomiya, et al.　Dig Liver Dis. 2009 Jun;41(6):390-4.

What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.
H Shiga, S Takagi, et al.　Digestion. 2010;81(2):104-12.

Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis.
E Nomura, Y Kinouchi, S Takagi, et al.　Genes Immun. 2004 Sep;5(6):477-83.

Panniculitis of the descending colon caused by enterocolic phlebitis: a case report.
M Shiraki, S Takagi, et al.　Tohoku J Exp Med. 2004 Apr;202(4):299-304.

Photodynamic therapy of intestinal tumors with mono-L-aspartyl chlorin e6 (NPe6): a basic study.
T Kikuchi, T Asakura, S Takagi, et al.　Anticancer Res. 2003 Nov-Dec;23(6C):4897-900.

Relationship between microsatellite instability and telomere shortening in colorectal cancer.
S Takagi, Y Kinouchi, et al.　Dis Colon Rectum. 2000 Oct;43(10 Suppl):S12-7.

Strong telomerase activity of B lymphocyte from mesenteric lymph nodes of patients with inflammatory bowel disease.
S Takagi, Y Kinouchi, et al.　Dig Dis Sci. 2003 Oct;48(10):2091-4.

Telomere shortening in the colonic mucosa of patients with ulcerative colitis.
Y Kinouchi, N Hiwatashi, S Takaghi, et al.　J Gastroenterol. 1998 Jun;33(3):343-8.

Effect of weekend 5-aminosalicylic acid (mesalazine) enema as maintenance therapy for ulcerative colitis: results from a randomized controlled study.
H Yokoyama, S Takaghi, et al.　Inflamm Bowel Dis. 2007 Sep;13(9):1115-20.

High Ki-67 labeling index in human colorectal cancer with microsatellite instability.
S Takagi, S Kumagai, et al.　Anticancer Res. 2002 Nov-Dec;22(6A):3241-4.

Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
S Takagi, Y Kinouchi, et al.　Anticancer Res. 2002 Sep-Oct;22(5):2749-52.

Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients.
K Negoro, S Takahashi, S Takagi, et al.　Dis Colon Rectum. 2000 Oct;43(10 Suppl):S29-33.

Useful endoscopic findings for early diagnosis of ulcerative colitis associated colorectal cancer.
Y Sato, S Takagi, et al.　Endoscopy. 2008 Sep;40 Suppl 2:E71-2.

Prognostic and diagnostic significance of tumor budding associated with β-catenin expression in submucosal invasive colorectal carcinoma.
K Umemura, S Takagi, et al.　Tohoku J Exp Med. 2013 Jan;229(1):53-9.

Lack of association between IBD5 and Crohn’s disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.
M Tosa, K Negoro, S Takagi, et al.　Scand J Gastroenterol. 2006 Jan;41(1):48-53.

Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14.
N Obana, S Takahashi, S Tkagi, et al.　Scand J Gastroenterol. 2002 Jun;37(6):699-704.

Microsatellite instability and loss of heterozygosity in the nondysplastic colonic epithelium of ulcerative colitis.
S Takahashi, Y Kojima, S Takagi, et al.　J Gastroenterol. 2003;38(8):734-9.

Crohn’s disease is associated with novel polymorphisms in the 5′-flanking region of the tumor necrosis factor gene.
K Negoro, Y Kinouchi, S Takagi, et al.　Gastroenterology. 1999 Nov;117(5):1062-8.

Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas.
S Takagi, Y Kinouchi, et al.　Cancer. 1999 Oct 15;86(8):1431-6.